C-reactive protein and cold-pressor tolerance in the generalpopulation: PAIN – July 2017
I’m reposting this study because it explains that hyperalgesia, which is blamed on opioids, arises from chronic inflammation and the numerous chemical changes this causes in the body over time.
Pain and inflammation are related:
systemic inflammation may lead to a variety of pain states, and, in turn, persistent pain causes an upward adjustment of proinflammatory mediatorsthat sometimes elicit a prolonged low-grade immune response, leading to long-lasting, subclinical inflammation.
The cytokines that are produced during inflammatory responses are the main stimulators of the production of acute-phase proteins, specifically C-reactive protein (CRP).
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